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Histone-mediated epigenetics in addiction.73 Mood Disorders edit Depression is associated with reduced motivation, as assessed by willingness to expend effort for reward."Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation"."Planning" means setting performance expectations and goals for groups and individuals to channel their efforts toward achieving organizational objectives.This study, in agreement with the results obtained with microiontophoresis, suggests that D2R-containing SPNs play a more prominent role in promoting motivation than originally anticipated.Current Opinion in Behavioral Sciences.Yes, thankfully there are! .
Walker DM, Nestler EJ (2018).

9 However, dopamine is not the only reward compound in the brain.The transcription mud pie gifts sale factor delta FosB is increased in the NAc, PFC, dorsal striatum, and VTA following repeated sexual behavior (Wallace., 2008; Pitchers., 2010b).Soares-Cunha, C; Coimbra, B; Sousa, N; Rodrigues, AJ (September 2016)."Cognitive and Motivational Neuroscience of Psychotic Disorders".On the other hand, intense euphoria is harder to come by than everyday pleasures.Some of these proposed interventions have limitations (125) or are in their infancy (75).Finally, periods of abstinence from sexual experience were found to be critical for enhanced Amph reward, NAc spinogenesis (Pitchers., 2010a and glutamate receptor trafficking (Pitchers., 2012).Activation of the iMSNs, however, causes a net inhibition of thalamic activity resulting in a negative cortical feedback loop and therefore serves as a 'brake to inhibit behavior."Ventral tegmental area: cellular heterogeneity, connectivity and behaviour".